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KMID : 0381019870200010046
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Korean Journal of Nutrition
1987 Volume.20 No. 1 p.46 ~ p.53
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Effect of Bile Deprivation on Serum Lipids and Gastrin in the Rat
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Abstract
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The effect of bile deprivation on serum lipid and gastrin contents was investigated after choledocho -urinary cystostomy in Sprague-Dawley rats. Bile deprivated rats were compared with sham operated control group. Gastrin levels in serum and antral tissue were measured and serum lipid concentrations were also measured.
Gastrin levels of serum and tissue after bile deprivation were increased significantly compared with those of the control. At the end of 1st and 2nd week after bile deprivation, serum cholesterol and triglyceride contents were significantly lower han those of the control. By 4th week, there was no significant difference bet-we :n two groups. Increases in serum and antral gastrin levels temporarily coincided well with decreases in serum lipid contents after bile deprivation. These resu´.ts suggest that there is increase in biosynthesis and release of gastrin and decrease in fat absorption at early stage of bile deprivation.
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